Prednisone instructions for use price and reviews

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Instructions for use is a synthetic analogue of hydrocortisone. Available in 5 mg tablets, it has anti-inflammatory, immunosuppressive and antihistamine effects.


Prednisolone tablets are prescribed for the following pathologies:

  • rheumatic heart disease, rheumatic chorea and fever;
  • systemic connective tissue diseases, including SLE, systemic scleroderma, polyarteritis nodosa;
  • multiple sclerosis;
  • malignant neoplasms in the lungs (in combination with cytostatic agents);
  • congenital and acquired adrenal insufficiency;
  • tuberculosis, including tuberculous meningitis, in parallel with other medicines;
  • inflammation of the liver;
  • lowering blood sugar levels;
  • inflammatory diseases of the digestive system, including regional enteritis, NUC, local enteritis;
  • joint diseases accompanying inflammation (inflammation of the joint capsule and synovium, nonspecific inflammation of the tendons, epicondylitis, arthritis of any etiology, polyarthritis, Still’s disease in adults, periarthrosis of the shoulder scapula, osteoarthritis);
  • congenital adrenal hyperplasia;
  • acute and chronic allergic reaction;
  • to prevent and eliminate nausea and vomiting during chemotherapy;
  • bronchial asthma, including those complicated by status asthmaticus;
  • to prevent organ rejection after transplantation;
  • an increased level of calcium, provoked by oncology;
  • edema of the brain of various etiologies (prescribed after injections of Prednisolone);
  • autoimmune diseases, including those of the skin;
  • dermatological diseases (eczema, pemphigus, seborrhea, toxic epidermal necrolysis, Duhring’s disease, exfoliative dermatitis);
  • diffuse infiltrative lung diseases (alveolitis in the acute phase, pneumosclerosis, 2 and 3 degrees of sarcoidosis);
  • Lyme disease, volatile pulmonary infiltrates, aspiration pneumonia (in combination with specific drugs);
  • de Quervain’s thyroiditis;
  • nephrotic syndrome;
  • labyrinthitis, mastoiditis;
  • diseases of the blood and hematopoietic organs (decrease in all blood corpuscles, plasmacytoma, leukemia);
  • allergic and autoimmune eye diseases.

How to take medicine and dosage

The tablets should be taken orally whole with a small amount of water.

The dosage is assigned individually, in the morning you need to take 2/3 of the dose, in the evening the remaining 1/3 of the dosage.

Treatment should not be stopped quickly, the dosage should be reduced gradually.

In the acute phase and as replacement therapy at the beginning of treatment, adults are prescribed medication in a daily dosage of 20 to 30 mg, then the dosage is reduced to 5-10 mg per day. If necessary, the initial daily dosage can vary from 15 to 100 mg, maintained from 5 to 15 mg.

In pediatrics, the drug is prescribed in a daily dosage of 1-2 mg per kg of the child’s weight, it must be taken in 4-6 doses, then they switch to a maintenance dosage of 300 to 600 μg per kg of body weight.


Prednisolone should not be taken in case of individual intolerance.

With caution, the medication should be prescribed to patients suffering from the following pathologies:

  • ulcer of the stomach and duodenal ulcer;
  • peptic ulcer in acute or latent phase;
  • inflammation of the stomach lining;
  • esophagitis;
  • diverticulitis;
  • UC with the threat of rupture of the intestinal wall or abscess formation;
  • tendency to thromboembolism;
  • a recent surgery to create an intestinal anastomosis;
  • acute and subacute phase of myocardial infarction;
  • high blood pressure;
  • systemic fungal infection;
  • increased intraocular pressure;
  • systemic osteoporosis;
  • severe chronic heart failure;
  • infectious diseases of various etiologies, both in acute form and recently transferred, including contact with an infected person;
  • active and latent forms of tuberculosis;
  • increased and decreased thyroid function;
  • obesity 3 and 4 degrees;
  • 8 weeks before and 2 weeks after vaccination;
  • diabetes;
  • mental illness;
  • poliomyelitis, other than bulbar encephalitis;
  • lymphadenitis after BSG vaccination;
  • severe forms of renal and hepatic failure;
  • immunodeficiency;
  • hypercortisolism; severe muscle failure;
  • kidney stone disease;
  • hypoalbuminemia.

Application during pregnancy and lactation

In experiments on animals, a negative effect of Prednisolone on the course of pregnancy was found.

During the period of gestation (especially in the first 3 months) of a child, a medication is allowed to be prescribed only on strict indications.

With long-term administration of the drug, there is a small risk of underdevelopment of the soft palate in the child and intrauterine growth retardation.

When prescribing a medication in the last 3 months, it is possible that the fetus has atrophy of the adrenal cortex, as a result, the newborn will need replacement therapy.

The active substance is excreted in a minimum amount through the mammary glands, therefore it is advisable to transfer the child to the mixture during the treatment.


In case of overdose, there is an increase in undesirable effects, hypertension, edema of the extremities.

There is no antidote; in the acute form, gastric lavage is indicated; in chronic poisoning, the dosage must be reduced.

Side effects

The appearance and severity of adverse reactions depends on the dosage, duration of therapy, and consideration of the daily rhythm of glucocorticosteroid production.

While taking the drug, the following negative reactions may occur:

  • indigestion, bloating, hiccups, increased acidity of gastric juice, steroid ulcers in the digestive tract, erosive esophagitis, rupture of the gastrointestinal tract walls, nausea, vomiting, inflammation of the pancreas, loss or increased appetite, bleeding from ulcers, liver enlargement and impaired liver function;
  • high blood pressure, slowing heart rate, cardiac arrest, heart rhythm disturbances, changes in the electrocardiogram, characteristic of a decrease in potassium in the blood, the appearance or aggravation of heart failure, myocardial dystrophy;
  • in acute and subacute myocardial infarction, there is a risk of proliferation of the necrosis focus, a slowdown in the formation of scar tissue and the likelihood of rupture of the heart muscle;
  • increased blood clotting, the formation of blood clots and the risk of blockage of blood vessels;
  • ravenous hunger, weight gain, negative nitrogen balance;
  • a decrease in the level of potassium and calcium in the blood, an increase in the concentration of sodium in the blood;
  • myasthenia gravis, aseptic necrosis, muscle atrophy, osteoporosis, fractures of the vertebrae and tubular bones, rupture of the tendon-ligamentous apparatus, impaired skeletal formation in children;
  • steroid acne, excessive sweating, increased or weakened skin pigmentation, thinning of the skin, reddening of the facial skin, large and punctate hemorrhages in the skin and mucous membranes, allergic dermatitis;
  • delirium, paranoia, vertigo, headache, euphoria, false cerebellar tumor, sleep disturbance, intracranial pressure, hallucinations, convulsions, depression, disorientation, epilepsy, anxiety, manic-depressive psychosis;
  • lag in sexual development, increased activity of the RAAS, pain during menstruation, absence of menstruation, hairiness, adrenal insufficiency, progression of diabetes mellitus, dyslipidemia, withdrawal syndrome;
  • the development of infectious diseases of various etiologies, proptosis, trophic changes in the cornea, opacity of the lens, increased intraocular pressure with damage to the optic nerve;
  • weakening of the immune system, fatigue, slow wound healing, allergic rashes, itching, anaphylaxis, steroid angiitis.


Each tablet contains 5 mg of prednisolone.

As auxiliary substances, the tablets include:

  • corn and potato starch;
  • pyrogenic silicon dioxide;
  • talc;
  • polyvinylpyrrolidone;
  • octadecanoic acid;
  • magnesium stearate;
  • milk sugar.

Pharmacology and pharmacokinetics

The active substance has anti-inflammatory, immunosuppressive, anti-shock and antihistamine effects.

Acts on all types of metabolism, when it is taken, the following effects are observed:

  • gluconeogenesis is activated, at the same time peripheral glucose utilization can decrease, which will provoke its increase in blood and urine;
  • protein synthesis decreases, albumin production increases, protein breakdown can accelerate;
  • the formation of IVH and fats increases, with their deposition in the upper body;
  • sodium is retained in the body, potassium and calcium are excreted through the kidneys.

After oral administration, it is rapidly absorbed from the digestive tract. The maximum concentration is observed after 1-1.5 hours. The half-life from plasma is 2-4 hours, from tissues 18-36 hours. It is excreted in the urine.

Terms of sale and storage

Prednisolone is dispensed by prescription. You need to store the tablets in a dark place where children cannot reach them, at a temperature of 15 to 30 degrees.

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