The most famous drug for potency Viagra has many disadvantages. Firstly, it is impossible to take it discreetly and the manifestation of the effect must be expected. Secondly, many are frightened off by unpleasant side effects. But most importantly – Viagra does not help everyone. What to do? Try to buy Tadalafil. Possessing the same principle, Tadalafil acts more selectively, more strongly and more quickly.
Tadalafil – what is it?
What is tadalafil? It is a PDE-5 inhibitor that is widely used to treat erectile dysfunction. This term refers to the condition of the male body, in which the genital organ cannot achieve an erection sufficient for sex. Tadalafil has a mild, safe effect on the body, a long period of action. For example, Sildenafil acts for 4 hours. More recently, it was the only medicine against impotence. Today in the market Tadalofil has strongly pressed him. Statistics say that every month, https://stop-ed-meds.com/ tablets are becoming more popular. Recently, attempts have often been made to give Tadalafil to women. But in this regard, the drug has not been studied enough. Since it was allowed to be sold in the USA, Tadalafil has become the most popular remedy for impotence. Chemical formula:
Active ingredient Tadalafil: history of creation
The active substance Tadalafil was developed as part of a partnership between the pharmacological companies ICOS and GlaxoSmithKline (at that time Glaxo Wellcome). The first experiments were carried out as far back as 1991. Then Tadalafil appeared. As in the case of Sildenafil, the new drug was originally intended to treat other diseases. Only when Pfizer announced the ability of Viagra to enhance an erection, ICOS Corporation decided to test Tadalafil for these purposes. The patent was obtained in 1994. In 1997, the second phase of clinical trials of the active substance Tadalafil began. A drug based on it was approved by the FDA in 2003.
In 1998, the venture company Lilly ICOS, LLC was founded. For ten years, she continued to divide in half with GlaxoSmithKline the profit received from the sale of the drug Tadalafil, more about the action of which will be described below. In 2007, Eli Lilly and Company fully acquired ICOS Corporation. Since then, she owns the trademark Cialis Tadalafil). Production of the drug is also carried out by some Indian companies (for example, Cipla), but under a different name. Currently, two drugs based on the active ingredient Tadalafil are available. Name of drugs:
The trials of Tadalafil continue to this day. Perhaps, soon the question “which tablets contain Tadalafil” will give a more detailed answer. Since May 2009, Tadalafil tablets have also begun to be used to treat pulmonary hypertension.
How does tadalafil work?
The mechanism of action of tadalafil is based on the blocking of PDE-5. With sexual arousal in the cavernous bodies, local excretion (NO) occurs. Combining with guanylate cyclase, nitrogen monoxide forms cyclic guanosine monophosphate. This compound is responsible for the relaxation of smooth muscles. As long as the muscles at the root of the penis are tense, the blood cannot reach the cavernous bodies in sufficient quantities. The described process in the presence of erectile dysfunction is disrupted by the cGMP-specific enzyme type 5 phosphodiesterase.
So why is tadalafil needed? Through the stomach, the active substance enters the bloodstream very quickly. It blocks the action of PDE-5, increasing blood flow in the genital area. As a result, the cavernous bodies are maximally absorbed by the blood, greatly increasing in size. It must be borne in mind that medicines containing tadalafil help restore the natural, natural mechanism of erection. Without sexual stimulation, there will be no arousal.
As you know, PDE-5 inhibitors are not only medicines containing tadalafil. In a similar way, Sildenafil and Vardenafil fight erectile dysfunction. However, recent studies have shown that drugs with the active ingredient Tadalafil to a much lesser extent affect type 6 phosphodiesterase. This enzyme is found in the eyes. Unlike Levitra and Viagra, preparations based on Tadalafil practically do not affect the PDE-1 enzyme located in the brain and capable of causing hyperemia, tachycardia (information from Tadalafil radar).
How does tadalafil affect women?
It is still not known for certain how Tadalafil acts on women. The female genital organ (vagina) is excited in much the same way as the male (penis). Therefore, attempts are periodically made to develop female Tadalafil. True, so far they have not been successful. To determine exactly whether women can take Tadalafil, additional research is needed. It was reported that letters to the manufacturer’s mail quite often came with a single question: “Can Tadalafil be for women?” This forced the company to add a separate paragraph to the instructions that stated that drugs containing Tadalafil for women were not intended.
Regardless of which Tadalafil-based tablets you take, they will always act the same. “Cialis” helps to fully restore the sexual function of the male body. Tadalafil tastes bitter, so it is better to swallow it immediately and drink it with water. After taking, after a while, the ability to sexual activity appears. When registering a patent for Tadalafil, the manufacturer indicated a validity period of 36 hours. However, there is evidence that drugs containing Tadalafil in many men are valid for two days. Therefore, they are called “medicine for the weekend.”
Tadalafil: indications for use
Currently, drugs with tadalafil are used to treat the following diseases:
- pulmonary hypertension;
- benign prostatic hyperplasia;
- erectile disfunction.
The disease that Tadalafil was originally intended to treat is pulmonary hypertension. During the 16-week RCT, scientists found that compared to the placebo group, patients taking 2.5–40 mg of the drug felt a significant improvement. A recent study showed that Tadalafil with pulmonary hypertension really alleviates the condition of the patient. However, the drug does not seem to eliminate the risk of death.
Preparations containing Tadalafil are used in the treatment of benign prostatic hyperplasia. Symptoms such as frequent urination, weak urine flow, frequent nightly urination, incomplete emptying of the bladder, etc. are characteristic of this disease. However, Tadalafil with adenoma cannot be combined with taking alpha blockers. This can lead to a dangerous decrease in pressure. Preparations containing tadalafil should also not be combined with nitrate-containing drugs.
Most often, tadalafil is used to treat erectile dysfunction. It has been described above how tadalafil works. The drug helps to overcome any degree of impotence. The principle of action of tadalafil is the same as that of other PDE-5 inhibitors. An important difference is the lasting effect. As already mentioned, the effect of Tadalafil on women is not well understood. Therefore, drugs with tadalafil are recommended for men only. On the Web you can find reviews of women who took Tadalafil. Those who drank the medicine noted some sensation relief.
Tadalafil preparations can be taken once or daily. For daily use, a dosage of 5 mg is used. In this case, avoid skipping the drug Tadalafil. The course of treatment for erectile dysfunction is 1 week. Tadalafil, the effect of which is described above, can also be used to treat prostate adenoma. This disease is treated for 1 month. Although usually Tadalafil preparations cause a positive effect after 2 weeks.
You can also take once (if necessary) a medicine that contains tadalafil. How to drink it in this case? Despite the fact that the active substance Tadalafil begins to act in 15-20 minutes, doctors recommend taking the pill about 45-60 minutes before sex. This can be done before, during or after a meal. Tadalafil-containing drugs do not become less effective due to the fat content of the food. Tadalafil tastes bitter, and food can drown out this flaw.
Currently, production of Tadalafil in tablets with a content of 2.5, 5, 10 and 20 mg has been established. 5 mg tablets are used for daily use, and 10 and 20 mg for single use. A dosage of 2.5 mg was approved by the FDA later (in 2009). It is used to adjust the daily amount of the active substance. Adcirca, a drug containing tadalafil and used to treat prostate adenoma, is available in 40 mg tablets.
The drug Tadalafil, the mechanism of action of which we examined above, is characterized by good tolerability. It can be taken at any age. Therefore, even men over 65 years old are often prescribed tadalafil. The method of application remains unchanged. For 24 hours, a maximum of one tablet is allowed. Tadalafil for women is not used.
Professionals are often asked questions: “Is Tadalafil harmful?” “Is tadalafil dangerous?” This active substance is well studied. It is safe to say that one of the most non-hazardous drugs is Tadalafil. Safety, however, depends on how the man adheres to the instructions for use. During the third (final) phase of clinical trials, patients (with their consent) were given the drug once in a dose of up to 500 mg and repeatedly up to 100 mg per day. This did not cause an increase in side effects. Therefore, Tadalafil is considered one of the safest drugs for potency. Addiction to the drug does not occur.
Tadalafil and alcohol
Tadalafil does not interact with alcohol. True, excessive consumption of low alcohol and strong alcohol-containing drinks can cause side effects. Therefore, tadalafil (medicine) is allowed to combine with alcohol in small quantities. Usually we are talking about a maximum of three glasses of wine or portions of vodka.
Is Tadalafil harmful? As we have already said, following the instructions, it is absolutely harmless. But there are a number of diseases in which you can not use Tadalafil. Treatment can not be carried out with:
- irregular heartbeat, tendency to heart attacks;
- uncontrolled hypertension or hypotension;
- a stroke;
- stomach ulcer, problems with blood clotting;
- retinitis pigmentosa;
- propensities to priapism;
- penis deformity.
The drug Tadalafil, the formula of which is given at the very beginning, can not be combined with drugs from the following groups:
- nitrate-containing drugs;
- alpha blockers;
- HIV protease inhibitors;
- some antibiotics;
- other PDE-5 inhibitors.
In the drug Tadalafil, the onset of the effect is noted after 15-20 minutes. If an erection within 4 hours or more does not disappear, you should immediately consult a doctor.
Tadalafil: side effects
Tadalafil can cause side effects. This happens with any medication. The drug Tadalafil side effects usually go away within a few hours. The most common are:
The drug Tadalafil side effects may also be associated with the use of alcohol. A small amount of alcohol is allowed while taking the active substance Tadalafil. Alcohol itself can cause headache, dry mouth, and vomiting. Visual impairment from Tadalafil (increased photosensitivity, color rendering, etc.) are rare and temporary.
Generics with tadalafil
In 2003, the FDA approved the active ingredient Tadalafil. Drugs containing it could be produced only by firms involved in the development. A few years later, the patent for Tadalafil ended. India became the second state to master the release of the popular drug. Tadalafil from India is called a generic. It is absolutely no different from the original. The differences are noticeable only in price and name. Generic Tadalafil is several times cheaper. Despite this, they are no less, and often more effective.